DIET AND ITS MICROENVIRONMENT INFLUENCE THE HEALTH OF COLON

Ulcerative colitis (UC) is an autoimmune chronic inflammatory disease of the large intestine that greatly increases risks colorectal cancer. UC idiopathic disorder colonic mucosa, which starts in rectum and generally extends proximally a continuous manner through part of, or entire, colon. A Western diet, smoking, alcohol abuse, altered circadian rhythm dysbiotic microbiome thought to induce UC. However, it still not completely understood factors diet triggers Identification associated with will lead healthier lifestyle prevents In animal models we show standard rich fiber positively influenced health high fat protein negatively regulated caused obesity animals, paradoxically also reduced colon length significantly these animals. Animals feeding on had no energy fecal pellet demonstrating peinosis [hunger-like-condition; peina (Greek) hunger; osis condition] induced peripheral neuropathy animals; whereas animals was healthy longer neuropathy. Bacteria family Erysipelotrichaceae related inflammation-related disorders gastrointestinal tract fed diet; low levels valeric acid propionic Overall, impacts due poor metabolism its metabolome. Currently, anti-inflammatory drugs immune suppressors are prescribed for treatment, side-effects risk opportunistic infections limit quality treatment. Hence, there need new class biologics efficient Bin1 factor as determined by increase expression patients. models, showed attenuation BIN1 gene protected against We have developed innovative therapeutic strategy treat acts correcting leaky epithelial barrier function drives inflammation this setting. Specifically, recently administration our anti-Bin1 monoclonal antibody (Bin1 mAb 99D) sufficient mimic effect genetic downregulation preserve normal mucosa established mouse model UC, comparison control-treated mice exhibited severe lesions cell influx throughout mucosa. influence may be beneficial during immunotherapeutic treatment ulcerative colitis.